Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Antimicrobial Proteins01:23

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Surface Membrane Barriers01:18

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Antibiotic Selection00:57

Antibiotic Selection

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dupilumab in adolescents with moderate to severe atopic dermatitis: a 32-week real-world experience during the COVID-19 pandemic.

Clinical and experimental dermatology·2021
Same author

Bullous pemphigoid induced by m-TOR inhibitors in renal transplant recipients.

Journal of the European Academy of Dermatology and Venereology : JEADV·2014
Same author

New chemotherapeutic strategies against malaria, leishmaniasis and trypanosomiases.

Current medicinal chemistry·2012
Same author

In vitro compared activity of telithromycin and azithromycin against northwest Italian isolates of Streptococcus pyogenes and Streptococcus pneumoniae with different erythromycin susceptibility.

Letters in applied microbiology·2009
Same author

Phenotypic and genotypic characterization of Pseudomonas aeruginosa from cystic fibrosis patients.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2008
Same author

Pseudomonas aeruginosa and Burkholderia cenocepacia infections in patients affected by cystic fibrosis: serum resistance and antibody response.

Immunological investigations·2008
Same journal

PROTAC-Mediated Targeting of PARP via CRBN: Mechanistic Insights, Resistance Challenges, and Therapeutic Advancements.

Mini reviews in medicinal chemistry·2026
Same journal

Recent Advancements in the Development of Heterocyclic Scaffolds as Potential Anti-cancer Agents Targeting EGFR and VEGFR-2.

Mini reviews in medicinal chemistry·2026
Same journal

Exploring the Anticancer Potential of Synthetic β-Carboline Derivatives: A Comprehensive Systematic Review.

Mini reviews in medicinal chemistry·2026
Same journal

KIF20A in Human Malignancies: Oncogenic Mechanisms and Therapeutic Targeting Strategies.

Mini reviews in medicinal chemistry·2026
Same journal

Phytocompound-loaded Biomaterial-based Scaffolds: Emerging Strategies for Wound Healing Applications.

Mini reviews in medicinal chemistry·2026
Same journal

Bioprospecting of Natural Products as Sources of New Multitarget Therapies.

Mini reviews in medicinal chemistry·2026
See all related articles

Related Experiment Video

Updated: May 30, 2026

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

New antimicrobial frontiers.

M Zucca1, S Scutera, D Savoia

  • 1Department of Clinical and Biological Sciences, Faculty of Medicine S. Luigi Gonzaga, 10043, Orbassano, Torino, Italy.

Mini Reviews in Medicinal Chemistry
|July 26, 2011
PubMed
Summary
This summary is machine-generated.

New strategies for antimicrobial peptides and antivirulence factors are crucial to combat bacterial resistance. These novel approaches target essential bacterial structures, avoiding selective pressure and promoting effective infection control.

More Related Videos

Production and Testing of Antimicrobial Peptides and Their Mimics
10:35

Production and Testing of Antimicrobial Peptides and Their Mimics

Published on: April 10, 2026

Related Experiment Videos

Last Updated: May 30, 2026

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

Production and Testing of Antimicrobial Peptides and Their Mimics
10:35

Production and Testing of Antimicrobial Peptides and Their Mimics

Published on: April 10, 2026

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Drug Discovery

Background:

  • The rise of multi- and cross-resistant bacterial strains necessitates novel antimicrobial strategies.
  • Traditional semi-synthetic antibiotics, derived from existing molecules, face limitations due to inherent selective pressure.
  • Targeting specific enzymes in bacteria leads to the emergence of resistant strains.

Purpose of the Study:

  • To review emerging antimicrobial strategies that circumvent bacterial resistance.
  • To explore the potential of antimicrobial peptides and antivirulence factors.
  • To highlight approaches that avoid selective pressure on bacterial populations.

Main Methods:

  • Comprehensive literature review of recent scientific publications.
  • Analysis of novel antimicrobial development strategies.
  • Focus on targeting essential bacterial structures and antivirulence mechanisms.

Main Results:

  • Antimicrobial peptides and antivirulence factors represent promising alternatives to conventional antibiotics.
  • These novel agents target essential bacterial structures or virulence mechanisms, rather than specific enzymes.
  • This approach reduces the selective pressure that drives the development of bacterial resistance.

Conclusions:

  • Antimicrobial peptides and antivirulence factors offer a viable path to overcoming antibiotic resistance.
  • Future antimicrobial development should focus on these novel targets to ensure sustained control of infectious diseases.
  • Targeting essential structures and virulence factors is key to developing next-generation antimicrobials.