Cutaneous reactions to transdermal therapeutic systems

Area of Science:

• Dermatology
• Pharmacology
• Drug Delivery Systems

Background:

• Transdermal therapeutic systems (TTSs) are widely utilized for managing various medical conditions.
• While TTSs provide significant advantages in drug administration, adverse cutaneous reactions remain a frequent concern.

Purpose of the Study:

• To review and update information on skin reactions associated with transdermal therapeutic systems.
• To focus on medications recently introduced in transdermal therapeutic system formulations.

Main Methods:

• Literature review of adverse cutaneous reactions.
• Analysis of skin reactions linked to newly available TTS medications.

Main Results:

• Common adverse cutaneous reactions observed with TTSs include irritation, eczema, and allergic contact dermatitis.
• Specific medications reviewed for their associated skin reactions include buprenorphine, diclofenac, lidocaine, oxybutynin, rotigotine, methylphenidate, rivastigmine, teriparatide, and nicardipine.

Conclusions:

• Adverse cutaneous reactions are a significant consideration for patients using transdermal therapeutic systems.
• Healthcare providers should be aware of the potential for skin reactions with new TTS medications to ensure appropriate patient management.