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American Contact Dermatitis Society Core Allergen Series: 2020 Update.

Peter C Schalock1, Cory A Dunnick2, Susan Nedorost3

  • 1From the Department of Dermatology, Geisel School of Medicine at Dartmouth, Hanover, NH.

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Summary

The American Contact Dermatitis Society updated its core allergen series for 2018, removing one allergen and adding eleven new ones. This revision aims to improve the identification of relevant positive reactions in patients with contact dermatitis.

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Area of Science:

  • Dermatology
  • Allergology
  • Toxicology

Background:

  • The American Contact Dermatitis Society (ACDS) established a Core Allergen series in 2013, updated in 2017.
  • Periodic updates are necessary to reflect current allergen prevalence and clinical relevance.

Purpose of the Study:

  • To revise the ACDS Core Allergen series based on recent data.
  • To enhance the diagnostic yield of patch testing for contact dermatitis.

Main Methods:

  • Analysis of the ACDS Contact Allergen Management Program's top 100 allergens from 2018.
  • Revision of the recommended allergen series, including removal and addition of specific haptens.

Main Results:

  • Methyldibromoglutaronitrile was removed from the core series.
  • Eleven new haptens were added: Lyral, Limonene, Linalool, carmine, benzyl salicylate, disperse yellow 3, jasmine, peppermint, pramoxine, shellac, and lauryl polyglucose (glucosides).

Conclusions:

  • The updated ACDS Core Allergen series incorporates new allergens identified from recent data.
  • These changes are expected to increase the detection rate of relevant positive patch test reactions in patients with suspected allergic contact dermatitis.