Related Experiment Video
Updated: May 30, 2026
10:14
An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
Published on: November 1, 2018
Glomerular disease
1North Carolina State University, College of Veterinary Medicine, Raleigh, NC 27606, USA. slvaden@ncsu.edu
Topics in Companion Animal Medicine
|July 26, 2011
Summary
Glomerular diseases in dogs often stem from acquired injuries, necessitating a thorough evaluation for underlying conditions. Management focuses on treating predisposing factors, proteinuria, and kidney complications, with prognosis varying by case.
Area of Science:
- Veterinary Nephrology
- Canine and Feline Medicine
Background:
- Glomerular diseases are a primary cause of chronic kidney disease in dogs, though less prevalent in cats.
- Diagnosis often requires renal biopsy due to the diversity of glomerular diseases.
- Acquired glomerular injury, frequently immune-complex mediated or systemic, is common in dogs, often linked to other diseases.
Purpose of the Study:
- To discuss the general diagnosis and management of glomerular disease in dogs.
- To highlight the importance of evaluating for predisposing disorders in dogs with suspected glomerular disease.
Main Methods:
- Review of current understanding of canine glomerular diseases.
- Discussion of diagnostic approaches, including renal biopsy.
- Outline of general management strategies: treating underlying causes, managing proteinuria, and addressing uremia.
Main Results:
- Most dogs develop acquired glomerular injury rather than familial forms.
- A comprehensive clinical evaluation for predisposing conditions is crucial.
- Management includes addressing underlying disorders, proteinuria, and kidney complications.
Conclusions:
- Glomerular disease diagnosis in dogs requires a thorough evaluation for underlying systemic or immune-mediated conditions.
- Management strategies are largely supportive and focus on predisposing factors and complications.
- Prognosis is variable and depends on the specific disease and overall health of the animal.
Related Concept Videos
01:20Renal Corpuscle
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
01:10Nephrons
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
01:24Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
01:28Diabetic Nephropathy
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
01:29Acute Kidney Injury II: Pathophysiology
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
01:28Chronic Kidney Disease III: Interprofessional Care
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...