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Related Experiment Videos

Group C rotavirus infection and infiltration.

Y Ishimaru1, H Nakano, M Oseto

  • 1Ishimaru Pediatric Clinic, Matsuyama, Japan.

Acta Paediatrica Japonica : Overseas Edition
|October 1, 1990
PubMed
Summary

Atypical rotavirus (RV) group C caused gastroenteritis in older children and adults. This group C RV was identified during a group A RV outbreak, showing milder symptoms and affecting those aged four and above.

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Area of Science:

  • Virology
  • Epidemiology
  • Pediatrics

Background:

  • Gastroenteritis outbreaks can involve atypical pathogens.
  • Rotavirus (RV) is a common cause of gastroenteritis, with Group A being most prevalent.

Purpose of the Study:

  • To identify the causative agent of an unusual gastroenteritis outbreak.
  • To investigate the prevalence and characteristics of atypical rotavirus Group C.

Main Methods:

  • Polyacrylamide gel electrophoresis (PAGE) to analyze viral RNA profiles.
  • Immune electron microscopy (IEM) for viral strain identification.
  • Serological analysis of stored sera to determine antibody prevalence.

Main Results:

  • PAGE analysis identified 12 cases with RNA profiles similar to Group C RV.

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  • IEM confirmed one strain as Group C rotavirus.
  • Group C RV was detected in patients aged 4 years and older during a Group A RV outbreak.
  • Antibodies to Group C RV were found in 20-40% of individuals aged 4 years and older, but rarely in those under 3.
  • Clinical symptoms of Group C RV infection were generally milder than Group A RV.

    • Conclusions:

    • Atypical Group C rotavirus was responsible for a portion of the gastroenteritis cases during the study period.
    • Group C rotavirus appears to primarily affect older children and adults.
    • The prevalence of Group C rotavirus antibodies suggests prior or endemic circulation in the population.