Related Experiment Video
Updated: May 30, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Subacute toxicity of celecoxib on thyroid and testis of rats: Hormonal and histopathological changes
Güldeniz Selmanoğlu1, E Arzu Koçkaya, M Turan Akay
1Hacettepe University, Faculty of Science, Department of Biology, 06800 Beytepe Campus, Ankara, Turkey.
Abstract:
Celecoxib is an effective agent in the treatment of signs and symptoms of inflammation, rheumatoid arthritis and osteoarthritis. The purpose of this study is to assess the effects of two different doses of celecoxib on some hormones and endocrine glands of male rats. In this study, the doses of 10 and 50mg/kg/day of celecoxib were given to male rats orally for 28 days. At the end of the study, serum total triiodothyronine (T(3)), total thyroxine (T(4)), thyroid stimulating hormone (TSH), testosterone and luteinizing hormone (LH) levels of rats were analyzed by radioimmunoassay technique using RIA kits. Thyroid and testis tissues of male rats were examined histopathologically. While there was no a change in serum T(3), T(4) and LH levels of celecoxib-treated rats, there were differences in serum TSH and testosterone levels of rats treated with 50mg/kg/day celecoxib for 28 days compared with those of control rats. In histopathological examinations, celecoxib-related changes were found in thyroid glands of the rats.
Related Concept Videos
Toxicity Testing in Animals
Hyperthyroidism II: Pathophysiology
Drug Toxicity: Dose-Dependent Reactions
Hypothyroidism II: Pathophysiology
