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Updated: May 30, 2026

MicroRNA-based Regulation of Picornavirus Tropism
Published on: February 6, 2017
Antiviral effects of human microRNAs and conservation of their target sites
Aniello Russo1, Nicoletta Potenza
1Department of Life Sciences, Second University of Naples, Caserta, Italy. aniello.russo@unina2.it
Abstract:
MicroRNAs are small non-coding RNAs that modulate gene expression at post-transcriptional level, playing a crucial role in cell differentiation and development. Recently, some reports have shown that a limited number of mammalian microRNAs also display antiviral effects. This article summarizes the data in the field paying a special attention to the conservation of the microRNA target sequences in the viral populations. This issue is relevant both for the evaluation of the biological significance of the antiviral effects and for the development of microRNA-based strategies for antiviral intervention.
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