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Related Concept Videos

Transgenic Organisms00:53

Transgenic Organisms

Overview
Transgenic Organisms00:53

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Allergic Reactions02:06

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Plant Breeding and Biotechnology01:59

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Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.
Transgenic Plants02:50

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Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically modified organisms are called transgenic organisms.
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...
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Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

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Published on: June 29, 2021

Endogenous allergen upregulation: transgenic vs. traditionally bred crops.

Rod A Herman1, Gregory S Ladics

  • 1Dow AgroSciences LLC, 9330 Zionsville Rd., Indianapolis, IN 46268, USA. raherman@dow.com

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|July 26, 2011
PubMed
Summary
This summary is machine-generated.

Transgenic crop safety assessments evaluate allergy potential. Transgenesis is unlikely to increase endogenous allergen levels more than traditional breeding, with unclear consequences.

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Area of Science:

  • Agricultural Science
  • Food Safety
  • Biotechnology

Background:

  • Current transgenic crop safety assessments include evaluating endogenous allergy potential using serum IgE screening for commonly allergenic foods.
  • This evaluation is particularly relevant given recent calls to quantify specific allergen concentrations in raw agricultural products.

Purpose of the Study:

  • To examine the utility of endogenous allergy potential analysis in transgenic crop safety assessments.
  • To compare the risks of allergen upregulation via transgenesis versus traditional breeding methods.

Main Methods:

  • Review of current safety assessment protocols for transgenic crops.
  • Analysis of the potential for allergen upregulation through genetic modification compared to conventional breeding.

Main Results:

  • The likelihood of transgenesis upregulating an endogenous allergen is not greater than that of traditional breeding.
  • Traditional breeding, despite a history of safety, is largely unregulated regarding allergen levels.

Conclusions:

  • The current approach to evaluating endogenous allergy potential in transgenic crops warrants examination.
  • The actual consequences of potentially upregulating endogenous allergens in food remain uncertain and require further investigation.