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Update to RIFM fragrance ingredient safety assessment, β-naphthyl isobutyl ether, CAS Registry Number 2173-57-1
A M Api1, A Bartlett1, D Belsito2
1Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.
Summary
This safety assessment indicates β-naphthyl isobutyl ether is safe for use. Evaluations for genotoxicity, toxicity, sensitization, and environmental impact show no concerns at current usage levels.
Area of Science:
- Chemical safety assessment
- Toxicology
- Environmental risk evaluation
Background:
- β-Naphthyl isobutyl ether is a chemical requiring comprehensive safety evaluation.
- Existing data and read-across from similar compounds inform its safety profile.
Purpose of the Study:
- To assess the safety of β-naphthyl isobutyl ether across multiple toxicological and environmental endpoints.
- To determine safe usage levels based on established toxicological thresholds and environmental standards.
Main Methods:
- Genotoxicity assays and read-across from β-naphthyl methyl ether.
- Repeated dose and reproductive toxicity assessments using Margin of Exposure (MOE) calculations.
- Evaluation of skin sensitization, photoirritation/photoallergenicity, and local respiratory toxicity.
- Environmental safety assessment including PBT criteria and risk quotient (RQ) analysis.
Main Results:
- β-Naphthyl isobutyl ether is not expected to be genotoxic.
- Calculated MOE values for repeated dose and reproductive toxicity are >100.
- No safety concerns for skin sensitization, photoirritation/photoallergenicity, or local respiratory toxicity.
- The substance is not Persistent, Bioaccumulative, and Toxic (PBT), with RQs <1 across major global regions.
Conclusions:
- The available data support the safe use of β-naphthyl isobutyl ether as described.
- No significant toxicological or environmental risks were identified at current declared levels of use.
- The chemical meets International Fragrance Association (IFRA) environmental standards.
