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Updated: May 30, 2026

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans
Published on: December 19, 2014
Cell wall chitosan is necessary for virulence in the opportunistic pathogen Cryptococcus neoformans
Lorina G Baker1, Charles A Specht, Jennifer K Lodge
1Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8230, St. Louis, MO 63104, USA.
Abstract:
Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningoencephalitis. Its cell wall is composed of glucans, proteins, chitin, and chitosan. Multiple genetic approaches have defined a chitosan-deficient syndrome that includes slow growth and decreased cell integrity. Here we demonstrate chitosan is necessary for virulence and persistence in the mammalian host.
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