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Primary central nervous system mucosa-associated lymphoid tissue lymphoma--case report
Yuuta Kamoshima1, Yutaka Sawamura, Taku Sugiyama
1Department of Neurosurgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan. kamoshima2002@yahoo.co.jp
Neurologia Medico-Chirurgica
|July 26, 2011
Summary
This study reports a rare case of primary central nervous system mucosa-associated lymphoid tissue (MALT) lymphoma in a 55-year-old woman. Local irradiation led to complete remission and no recurrence for three years.
Area of Science:
- Neurology
- Oncology
- Pathology
Background:
- Primary central nervous system (CNS) mucosa-associated lymphoid tissue (MALT) lymphoma is an exceptionally rare condition.
- MALT lymphomas typically arise in extranodal sites, with CNS involvement being infrequent.
Observation:
- A 55-year-old woman presented with seizures, later diagnosed with a left frontal dural mass.
- Magnetic resonance imaging (MRI) revealed a dural mass with surrounding edema.
- Histopathology confirmed MALT lymphoma with characteristic B-cell markers (CD20+) and absence of other specific markers (CD5, CD10, CD23, cyclinD1).
Findings:
- The patient received local irradiation therapy (40 Gy/20 fractions).
- Post-treatment MRI demonstrated complete remission of the dural MALT lymphoma.
- No systemic MALT lymphoma was detected, and the patient remained recurrence-free for three years without further treatment.
Implications:
- This case highlights the potential for MALT lymphoma to present as a primary CNS malignancy.
- Local irradiation appears to be an effective treatment modality for primary dural MALT lymphoma.
- Long-term surveillance is crucial for patients with primary CNS MALT lymphoma to monitor for recurrence or systemic spread.
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