Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 30, 2026

Visualizing Adhesion Formation in Cells by Means of Advanced Spinning Disk-Total Internal Reflection Fluorescence Microscopy
10:19

Visualizing Adhesion Formation in Cells by Means of Advanced Spinning Disk-Total Internal Reflection Fluorescence Microscopy

Published on: January 21, 2019

Dissecting cell adhesion architecture using advanced imaging techniques.

Penny E Morton1, Maddy Parsons

  • 1Randall Division of Cell and Molecular Biophysics, King's College London, London, UK.

Cell Adhesion & Migration
|July 26, 2011
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Monocytes and neutrophils promote cardiac fibroblast pro-fibrotic phenotypes through IL-6 and MIF.

Frontiers in cell and developmental biology·2026
Same author

Data modeling the interplay between single-cell shape, single-cell protein expression, and tissue state.

Cell reports methods·2026
Same author

Building capacity in imaging data management.

Journal of microscopy·2026
Same author

Development of three-colour FRET cascade for force sensing of the putative RIAM-vinculin interaction in fibroblasts.

Communications chemistry·2025
Same author

High content 3D imaging by dual-view oblique plane microscopy.

PNAS nexus·2025
Same author

Ligand and integrin-independent mechano-sensitive EGFR activation in lung cancer cells.

Journal of cell science·2025
Same journal

Abnormal expression of galectins and their correlation with fibrogenesis in adenomyosis.

Cell adhesion & migration·2026
Same journal

RBM15B-mediated m6A modification of FOXM1 activates the AURKA/TPX2 axis to promote epithelial-mesenchymal transition-driven endometrial cancer progression.

Cell adhesion & migration·2026
Same journal

Dynamic modulation of intercellular adhesion mediated by matriptase-EPCAM/Trop-2 axes is critical for cell extrusion, division, and collective migration.

Cell adhesion & migration·2026
Same journal

CXCL11 secreted by cancer-associated fibroblasts promotes nasopharyngeal carcinoma progression via CXCR3/PD-L1 axis.

Cell adhesion & migration·2026
Same journal

Meox1 promotes hepatocellular carcinoma progression potentially via regulation of cell cycle and p21 expression.

Cell adhesion & migration·2026
Same journal

STED/AFM as a tool to investigate mechanical and adhesive properties of migrating keratinocytes.

Cell adhesion & migration·2026
See all related articles

Cell adhesion structures, vital for development and healing, are complex protein networks. Advanced imaging reveals their intricate organization and hierarchical assembly, improving our understanding of cell signaling and dynamics.

Area of Science:

  • Cell biology
  • Biophysics
  • Molecular dynamics

Background:

  • Cell adhesion is crucial for embryonic development, tissue integrity, immune function, and wound healing.
  • Adhesions are complex macromolecular assemblies with over a hundred proteins regulating dynamics and signaling.
  • Previous research improved understanding of individual protein roles but lacked insight into sub-networks and sub-domains.

Purpose of the Study:

  • To provide an overview of recent data on cell:matrix and cell:cell contacts.
  • To highlight advances in imaging strategies for studying adhesion structures.
  • To explore the intricacies and hierarchy of proteins within cell adhesions.

Main Methods:

  • Review of recent biochemical and morphological analyses of cell adhesion.

More Related Videos

Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay
08:24

Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay

Published on: September 27, 2021

Quantification of Cell-Substrate Adhesion Area and Cell Shape Distributions in MCF7 Cell Monolayers
06:46

Quantification of Cell-Substrate Adhesion Area and Cell Shape Distributions in MCF7 Cell Monolayers

Published on: June 24, 2020

Related Experiment Videos

Last Updated: May 30, 2026

Visualizing Adhesion Formation in Cells by Means of Advanced Spinning Disk-Total Internal Reflection Fluorescence Microscopy
10:19

Visualizing Adhesion Formation in Cells by Means of Advanced Spinning Disk-Total Internal Reflection Fluorescence Microscopy

Published on: January 21, 2019

Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay
08:24

Imaging Molecular Adhesion in Cell Rolling by Adhesion Footprint Assay

Published on: September 27, 2021

Quantification of Cell-Substrate Adhesion Area and Cell Shape Distributions in MCF7 Cell Monolayers
06:46

Quantification of Cell-Substrate Adhesion Area and Cell Shape Distributions in MCF7 Cell Monolayers

Published on: June 24, 2020

  • Discussion of advanced optical techniques and imaging methods.
  • Analysis of studies focusing on protein sub-networks and sub-domains within adhesions.

    • Main Results:

    • Recent imaging advances have revealed intricate control of adhesion structure and assembly.
    • Understanding of protein sub-networks and distinct sub-domains within adhesions has significantly improved.
    • New insights into the spatial regulation and dynamics of adhesion signaling have emerged.

    Conclusions:

    • Advanced imaging techniques are essential for resolving the complex, sub-micron structures of cell adhesions.
    • Understanding the hierarchical organization of proteins within adhesions is key to deciphering their function.
    • Further research using these advanced methods will deepen our knowledge of cell adhesion's role in biological processes.