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Updated: May 30, 2026

Fertility Preservation in Patients with Severe Ovarian Dysfunction
Published on: March 25, 2021
Relationship between inhibin-α gene polymorphisms and premature ovarian failure in Korean women
Hoon Kim1, Sungwook Chun, Bon Seon Gu
1Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.
Objective:
The aim of this study was to determine the relationship between inhibin-α (INHα) gene polymorphisms and the prevalence of premature ovarian failure (POF) in Korean women.
Methods:
The INHα -124A/G, -16C/T, 679G/A, and 769G/A polymorphisms were analyzed in 52 women with POF and 55 normal healthy women using polymerase chain reaction-restriction enzyme fragment length polymorphism analysis.
Results:
The 679G/A and 769G/A polymorphisms were not observed. The frequencies of the C allele of the INHα -16C/T polymorphism and the G allele of the INHα -124A/G polymorphism were significantly lower in the women with POF than in the normal control women. The frequencies of the CG haplotype allele of these INHα -16C/T and -124A/G gene polymorphisms were also significantly lower in the women with POF than in the control women.
Conclusions:
The INHα -16C/T and -124A/G polymorphisms are genetic factors associated with the prevalence of POF in Korean women.
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