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Related Concept Videos

Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...

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Building the DREAM interactome.

Marcos Rivas1, Diego Villar, Paz González

  • 1Department of Molecular and Cellular Biology, National Center of Biotechnology, Consejo Superior Investigaciones Cientificas, Madrid, Spain.

Science China. Life Sciences
|July 26, 2011
PubMed
Summary
This summary is machine-generated.

DREAM, a calcium-binding protein, interacts with DNA and other proteins to regulate gene transcription and perform specialized functions. Understanding its protein interactions is key to deciphering DREAM's diverse physiological roles.

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Area of Science:

  • Molecular Biology
  • Neuroscience
  • Biochemistry

Background:

  • DREAM/calsenilin/KChIP3 is a calcium-binding protein within the neuronal calcium sensor superfamily.
  • DREAM plays a role in regulating gene transcription by interacting with DNA downstream regulatory elements (DRE).

Purpose of the Study:

  • To elucidate the diverse physiological functions of DREAM.
  • To characterize the protein interactions of DREAM, forming the DREAM interactome.

Main Methods:

  • Literature review of studies identifying DREAM-interacting proteins.
  • Analysis of known DREAM interactions with DNA and other proteins.

Main Results:

  • DREAM interacts with DRE sites on DNA to modulate transcription.
  • A growing list of interacting proteins has been identified, defining the DREAM interactome.
  • These interactions occur in various subcellular compartments, highlighting specialized functions.

Conclusions:

  • Understanding the DREAM interactome is crucial for comprehending its wide-ranging physiological functions.
  • DREAM's interactions with DNA and proteins underscore its significance in cellular regulation.