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Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats
Published on: May 24, 2018
Postnatal development of cochlear microphonic and compound action potentials in a precocious species, Chinchilla
Heath G Jones1, Kanthaiah Koka, Daniel J Tollin
1Neuroscience Training Program and Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, Colorado 80045, USA. Heath.jones@ucdenver.edu
Abstract:
The development of sound-evoked responses in Chinchilla lanigera was studied from postnatal ages P0-1 (first 24 h) to adult. Cochlear microphonic (CMs) and compound action potentials (CAPs), representing ensemble sound-evoked activities of hair cells and auditory nerve fibers, respectively, were present as early as age P0-1. The data indicate that CM thresholds and sensitivities were generally adult-like (i.e., fall into adult ranges) at birth, but suprathreshold CM amplitudes remained below adult ranges through P28. CAP thresholds reached adult-like values between P7-P14, but the suprathreshold CAP amplitude continued to increase until ∼P28. The results confirm the auditory precociousness of the chinchilla.
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