Related Experiment Video
Updated: May 30, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
Unraveling the ties between celiac disease and intestinal microbiota
Yolanda Sanz1, Giada De Pama, Moisés Laparra
1Institute of Agrochemistry and Food Technology, Spanish National Research Council, Valencia, Spain. yolsanz@iata.csic.es
Abstract:
Celiac disease is a multifactorial disorder that involves interactions between genetic and environmental factors. Gluten proteins are responsible for the symptoms of celiac disease, but other environmental factors that influence the intestinal ecosystem, including the milk-feeding type and gastrointestinal infections, may also play a role. Moreover, intestinal dysbiosis, characterized by increased Gram-negative bacteria and reduced bifidobacteria, has been detected in celiac disease patients. This review summarizes current knowledge of the associations between the intestinal microbiota and celiac disease and its possible modes of action in pathogenesis. Deeper understanding of these interactions can help redefine how this disorder is investigated.
Related Concept Videos
Dysbiosis of the Gut Microbiota
Microbiota of the Large Intestine
Introduction to the Human Microbiota
Functions of the Gut Microbiota
Inflammatory Bowel Disease III: Crohn's Disease
Anatomy of the Intestines
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the small...

