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Published on: November 5, 2019
Effect of mesoporous silica under Neisseria meningitidis transformation process: environmental effects under
Luciana M Hollanda1, Gisele Cg Cury, Rafaella Fc Pereira
1Department of Biochemistry, Institute of Biology CP6109, State University of Campinas UNICAMP, CP: 6109-CEP 13083-970, Campinas, SP, Brazil.
Background:
This study aimed the use of mesoporous silica under the naturally transformable Neisseria meningitidis, an important pathogen implicated in the genetic horizontal transfer of DNA causing a escape of the principal vaccination measures worldwide by the capsular switching process. This study verified the effects of mesoporous silica under N. meningitidis transformation specifically under the capsular replacement.
Methods:
we used three different mesoporous silica particles to verify their action in N. meningitis transformation frequency.
Results:
we verified the increase in the capsular gene replacement of this bacterium with the three mesoporous silica nanoparticles.
Conclusion:
the mesouporous silica particles were capable of increasing the capsule replacement frequency in N. meningitidis.
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