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Effects of repeated exposure to decabrominated diphenyl ether (BDE-209) on mice nervous system and its self repair

Shu-Xuan Liang1, Hong-Xia Gao, Yan-Yan Zhao

  • 1College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Heibei Province, Baoding 071002, PR China.

Environmental Toxicology and Pharmacology
|July 27, 2011
PubMed

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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...