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Ethanol tolerance in bacteria.

L O Ingram1

  • 1Department of Microbiology and Cell Sciences, University of Florida, Gainesville.

Critical Reviews in Biotechnology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Ethanol harms bacteria by increasing plasma membrane leakage, affecting growth and viability. Microbial ethanol tolerance largely depends on adaptive changes in cell membrane composition.

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Area of Science:

  • Microbiology
  • Biochemistry
  • Cell Biology

Background:

  • Ethanol exerts adverse effects on bacterial growth, viability, and metabolism.
  • These effects are primarily attributed to ethanol-induced plasma membrane leakage.
  • The biophysical properties of membranes in ethanolic solutions explain increased leakage.

Purpose of the Study:

  • To elucidate the mechanisms underlying ethanol's adverse effects on bacteria.
  • To investigate the role of cell membrane composition in microbial ethanol tolerance.
  • To clarify the differential tolerance of various cellular activities to ethanol.

Main Methods:

  • Analysis of ethanol's impact on bacterial plasma membrane integrity.
  • Assessment of adaptive and evolutionary changes in cell membrane composition.

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  • Comparative study of ethanol tolerance across different cellular functions.
  • Main Results:

    • Ethanol's primary action stems from colligative effects at high concentrations, not specific receptor interactions.
    • Bacterial ethanol tolerance is significantly influenced by adaptive changes in cell membrane composition.
    • Cellular activities exhibit varying tolerance to ethanol, with growth being most sensitive, followed by survival, and then glycolysis.

    Conclusions:

    • Ethanol-induced plasma membrane leakage is the principal cause of its detrimental effects on bacteria.
    • Microbial adaptation to ethanol involves modifications in cell membrane composition.
    • Defining specific cellular functions is crucial for accurate comparisons of ethanol tolerance.