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Bioactive saponins from the fruits of Aesculus pavia L
Zhen-Liang Sun1, Ming Zhang, Ying Wu
1Branch hospital in Fengxian of Shanghai No. 6 people's hospital, Shanghai 201400, PR China
Abstract:
Continued chemical investigation on the fruits of Aesculus pavia L. resulted in theisolation and identification of two new oleanolic acid saponins, namely vaccaroside A (1) andvaccaroside B (2). The isolated furostanol saponins were evaluated for cytotoxic activity againsthuman normal amniotic and human lung carcinoma cell lines using neutral red and MTT assays.In vitro experiments showed significant cytotoxicity in a dose dependent manner with IC₅₀ valuesin the range of 27.80-79.02 μM.
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