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Published on: March 29, 2018
CD34-positive developing vessels and other structures in human fetuses: an immunohistochemical study
Shin-ichi Abe1, Masashi Suzuki, Kwang Ho Cho
1Oral Health Science Center HRC8, Tokyo Dental College, Chiba, Japan. abesh@tdc.ac.jp
Surgical and Radiologic Anatomy : SRA
|July 27, 2011
Summary
CD34-positive cells, crucial for tissue regeneration, show distinct distributions in human fetuses. These cells are vital for vascular development and the structural organization of various tissues during fetal development.
Area of Science:
- Developmental Biology
- Histology
- Biotechnology
Background:
- CD34 is a known marker for progenitor cells in vascular and stromal tissues.
- CD34-positive cells are utilized in clinical settings for tissue regeneration.
- The in situ distribution of CD34-positive cells in the human fetus is largely undescribed.
Purpose of the Study:
- To investigate the distribution of CD34-positive cells in the human fetus.
- To understand the role of CD34-positive cells in fetal tissue development.
Main Methods:
- Immunohistochemistry was performed on 12 human fetuses (9-15 weeks of gestation).
- Analysis focused on the spatial arrangement of CD34-positive structures across different fetal tissues.
Main Results:
- CD34-positive structures exhibited vessel-like patterns in viscera, nerves, and lymph nodes.
- Diffuse fibrous distribution of CD34-positive cells was observed in the body wall and extremities.
- Myocardium, skeletal muscles (tongue, extraocular), fascia, and perimysium showed specific CD34 expression patterns.
- Lymphatic vessels were negative for CD34.
Conclusions:
- CD34-positive cells contribute to vascular development throughout the fetus.
- These cells appear critical for the pattern formation of skeletal muscle, synovial tissue, and associated connective tissues in human fetuses.
