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Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes02:31

Replication in Eukaryotes

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Related Experiment Video

Updated: May 30, 2026

Telomerase Activity in the Various Regions of Mouse Brain: Non-Radioactive Telomerase Repeat Amplification Protocol (TRAP) Assay
10:14

Telomerase Activity in the Various Regions of Mouse Brain: Non-Radioactive Telomerase Repeat Amplification Protocol (TRAP) Assay

Published on: September 2, 2014

Human telomerase expression regulation.

Marta Gladych1, Aneta Wojtyla, Blazej Rubis

  • 1Poznan University of Medical Sciences, Department of Clinical Chemistry and Molecular Diagnostics, Poland.

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
|July 28, 2011
PubMed
Summary
This summary is machine-generated.

Telomerase, crucial for cancer cell immortality, offers a promising anti-cancer therapy target. Understanding its transcriptional regulation in humans is key for developing new cancer treatments and insights into aging.

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Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
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Semi-quantitative Detection of RNA-dependent RNA Polymerase Activity of Human Telomerase Reverse Transcriptase Protein
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Semi-quantitative Detection of RNA-dependent RNA Polymerase Activity of Human Telomerase Reverse Transcriptase Protein

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Last Updated: May 30, 2026

Telomerase Activity in the Various Regions of Mouse Brain: Non-Radioactive Telomerase Repeat Amplification Protocol (TRAP) Assay
10:14

Telomerase Activity in the Various Regions of Mouse Brain: Non-Radioactive Telomerase Repeat Amplification Protocol (TRAP) Assay

Published on: September 2, 2014

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

Published on: April 13, 2015

Semi-quantitative Detection of RNA-dependent RNA Polymerase Activity of Human Telomerase Reverse Transcriptase Protein
08:26

Semi-quantitative Detection of RNA-dependent RNA Polymerase Activity of Human Telomerase Reverse Transcriptase Protein

Published on: June 12, 2018

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Telomerase is a key differentiator between cancer and normal cells, making it a significant therapeutic target.
  • Short telomere length is linked to increased mortality, highlighting the importance of telomerase activity in cancer therapy and prevention.
  • Telomerase, a complex enzyme, exhibits multi-level regulation, necessitating comprehensive study.

Purpose of the Study:

  • To review current knowledge on human telomerase regulation mechanisms at the transcriptional level.
  • To identify potential anti-cancer therapy targets within telomerase's regulatory pathways.
  • To explore the implications of telomerase research for stem cell metabolism and aging.

Main Methods:

  • Literature review of existing research on telomerase regulation.
  • Analysis of various proposed strategies to control telomerase activity in cancer cells.
  • Focus on transcriptional control of key telomerase subunits.

Main Results:

  • Telomerase activity is critical for cancer cell immortality and survival.
  • Multiple strategies exist to target telomerase, including genetic and chemical approaches.
  • Transcriptional control of telomerase subunits is a crucial factor in its overall activity.

Conclusions:

  • Understanding telomerase regulation, particularly at the transcriptional level, is vital for advancing cancer therapy.
  • Telomerase research offers insights into stem cell biology and the aging process.
  • Targeting telomerase transcription presents promising avenues for novel anti-cancer treatments.