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Lung spirometry parameters and diffusion capacity are decreased in patients with Type 2 diabetes
O L Klein1, R Kalhan, M V Williams
1Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. oklein@nmh.org
Summary
Patients with diabetes exhibit reduced lung function, including forced vital capacity and forced 1 s expiratory volume. This impairment is more pronounced in Caucasian individuals with diabetes compared to other racial groups.
Area of Science:
- Pulmonary Medicine
- Endocrinology
- Clinical Research
Background:
- Type 2 diabetes mellitus is linked to diminished lung function in prior cohort studies.
- Assessing lung function parameters like FVC, FEV1, and DLCO in relation to diabetes is crucial for understanding disease impact.
Purpose of the Study:
- To investigate the correlation between Type 2 diabetes mellitus and lung function measures (FVC, FEV1, DLCO).
- To analyze these correlations across different racial groups within a clinical setting.
Main Methods:
- Retrospective analysis of 4164 adult subjects' medical records from 2000-2009.
- Multiple linear regression used to compare lung function between diabetic and non-diabetic patients, adjusting for covariates.
- Race-specific analysis performed to examine differential effects.
Main Results:
- Diabetic patients (n=560) were older, more likely male, overweight, had heart failure, and were less likely Caucasian or never-smokers than non-diabetics (n=3604).
- Significant reductions in FVC, FEV1, and DLCO were observed in patients with diabetes (P < 0.0001), persisting after covariate adjustment.
- Only Caucasians with diabetes showed a significant decrease in all lung function measures after race stratification.
Conclusions:
- Diabetes mellitus is associated with significantly decreased lung function.
- Caucasian individuals with diabetes experience more global lung function impairment compared to African-Americans and Hispanics with diabetes.
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