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Reducing noninfectious risks of blood transfusion
Brian M Gilliss1, Mark R Looney, Michael A Gropper
1Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143-0624, USA.
Anesthesiology
|July 28, 2011
Summary
Noninfectious transfusion complications, like lung injury and circulatory overload, are now the leading causes of transfusion-related deaths in the U.S. Prevention strategies are discussed.
Area of Science:
- Transfusion Medicine
- Hematology
- Patient Safety
Background:
- Screening for transfusion-associated infections has improved significantly.
- Noninfectious complications now represent the majority of transfusion-related morbidity and mortality in the United States.
- Key examples include transfusion-related acute lung injury (TRALI), transfusion-associated circulatory overload (TACO), and hemolytic transfusion reactions.
Purpose of the Study:
- To review the leading noninfectious complications of blood transfusion.
- To discuss controversial preventive strategies for these complications.
Main Methods:
- Literature review of noninfectious transfusion complications.
- Discussion of selected preventive measures.
Main Results:
- Transfusion-related acute lung injury is the leading cause of transfusion-related death.
- Transfusion-associated circulatory overload is the second leading cause.
- Hemolytic transfusion reactions are the third leading cause.
Conclusions:
- Noninfectious complications are a critical area for transfusion safety improvement.
- Controversial prevention methods like universal leukoreduction, male-only plasma, and storage age restriction warrant further discussion and evaluation.
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