Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bile acid sequestrants.

M Ast1, W H Frishman

  • 1Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, New York.

Journal of Clinical Pharmacology
|February 1, 1990
PubMed
Summary

Bile acid sequestrants like cholestyramine effectively treat high LDL cholesterol in specific hyperlipoproteinemia types. These drugs slow atherosclerosis progression and can be combined with other lipid-lowering medications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of transient noise in Advanced LIGO relevant to gravitational wave signal GW150914.

Classical and quantum gravity·2020
Same author

GW150914: First results from the search for binary black hole coalescence with Advanced LIGO.

Physical review. D. (2016)·2020
Same author

Tests of General Relativity with GW170817.

Physical review letters·2019
Same author

Constraining the p-Mode-g-Mode Tidal Instability with GW170817.

Physical review letters·2019
Same author

Search for Subsolar-Mass Ultracompact Binaries in Advanced LIGO's First Observing Run.

Physical review letters·2018
Same author

GW170817: Measurements of Neutron Star Radii and Equation of State.

Physical review letters·2018

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Hypercholesterolemia, particularly type IIA and IIB hyperlipoproteinemia, is characterized by elevated LDL-cholesterol.
  • Effective management of high cholesterol is crucial for preventing atherosclerosis progression.

Purpose of the Study:

  • To review the efficacy and tolerability of bile acid sequestrants for hypercholesterolemia.
  • To highlight their role in managing atherosclerosis.

Main Methods:

  • Review of longitudinal clinical studies on bile acid sequestrants (cholestyramine, colestipol).
  • Analysis of drug interactions and side effect profiles.

Main Results:

  • Bile acid sequestrants are effective in lowering LDL-cholesterol in type IIA and IIB hyperlipoproteinemia.
  • These agents have demonstrated ability to slow atherosclerosis progression.
  • Generally tolerable side effect profile, primarily gastrointestinal.

Conclusions:

  • Bile acid sequestrants are a primary treatment for specific hypercholesterolemia.
  • They offer cardiovascular benefits by managing LDL-cholesterol and atherosclerosis.
  • Can be safely used in combination with other lipid-lowering therapies.

Related Experiment Videos