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Updated: May 30, 2026
Solid Plate-based Dietary Restriction in Caenorhabditis elegans
Published on: May 28, 2011
Paradoxical effect of severe dietary restriction on Long-Evans rat life span
François Abalan1, Willy Mayo, Hervé Simon
1Charles Perrens Hospital, and Institut François Magendie, Inserm U862-University of Bordeaux II, 33076 Bordeaux-Cedex, France. fabalan@ch-perrens.fr
Abstract:
It has been firmly established that the longevity of 20- to 60%-calorie-restricted rodents, with malnutrition (essential nutrients deficiency) being avoided, is increased when compared to ad libitum fed rodents. However, the effects on life span of severe dietary restriction (i. e. malnutrition), with limited weight loss, remained unknown. The purpose of this 4-year study was to investigate the effects on longevity of a severe form of dietary restriction, with limited and controlled weight loss. To this end, a group of male Long-Evans rats severely dietary restricted (SDR group), with a weight loss throughout the experiment
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