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Updated: May 30, 2026

Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
Inflammation-mediated obesity and insulin resistance as targets for nutraceuticals
Myung-Sunny Kim1, Myeong Soo Lee, Dae Young Kown
1Korea Food Research Institute, Gyongki-do, Republic of Korea.
Abstract:
Obesity-induced inflammation plays an important role in the development of insulin resistance, type 2 diabetes (T2D), and metabolic dysfunctions. Chronic activation of proinflammatory pathways within insulin target cells can lead to obesity-related insulin resistance. The inflammatory mediators consist of immune cells, cytokines, adipokines, and inflammatory signaling molecules. Targeting obesity-associated inflammation has been shown to protect experimental animals and human subjects from obesity-induced insulin resistance. Modulation of the inflammatory responses associated with obesity may help prevent or improve obesity-induced metabolic dysfunctions. In this review, we introduce the beneficial effects of nutraceuticals for targeting inflammation in the treatment of obesity-induced insulin resistance and metabolic dysfunctions.
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