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Related Concept Videos

Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
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A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
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Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...

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[NeuroBehçet: A case].

Germán Latorre González1, Ana Belén Escribano Gascón, Carlos López de Silanes de Miguel

  • 1Hospital Clínico San Carlos, Madrid, España.

Reumatologia Clinica
|July 29, 2011
PubMed
Summary
This summary is machine-generated.

NeuroBehçet, a rare neurological complication of Behçet's disease, can manifest with diverse symptoms. This case highlights a rare presentation involving both brainstem lesions and sinus thrombosis, successfully treated with corticosteroids.

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Area of Science:

  • Neurology
  • Rheumatology
  • Immunology

Context:

  • Behçet's disease is a systemic inflammatory disorder.
  • Neurological involvement (NeuroBehçet) affects approximately 5% of patients.
  • NeuroBehçet can present with varied neurological manifestations.

Purpose:

  • To report a rare case of NeuroBehçet.
  • To describe a unique presentation of both parenchymal and non-parenchymal neurological involvement.
  • To emphasize the diagnostic and therapeutic considerations in such cases.

Summary:

  • A 28-year-old male with a history of oral/genital ulcers and folliculitis presented with fever, headache, cranial nerve palsy, and limb paresis.
  • Cerebrospinal fluid analysis revealed pleocytosis and elevated protein.
  • Cerebral MRI demonstrated brainstem lesions and transverse sinus thrombosis.

Impact:

  • This case underscores the importance of considering NeuroBehçet in patients with characteristic systemic symptoms and neurological deficits.
  • The coexistence of parenchymal and non-parenchymal lesions is rare but manageable.
  • Early diagnosis and immunosuppressive treatment, such as corticosteroids, lead to favorable outcomes.