Efficient H2 production via Chlamydomonas reinhardtii
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Updated: May 30, 2026

Observation of Photobehavior in Chlamydomonas reinhardtii
Published on: May 6, 2022
Maria G Esquível1, Helena M Amaro, Teresa S Pinto
1Instituto Superior de Agronomia/Centro de Botânica Aplicada à Agricultura, Calçada da Tapada, 1349-017 Lisboa, Portugal.
Abstract:
Molecular hydrogen (H(2)) obtained from biological sources provides an alternative to bulk chemical processes that is moving towards large-scale, economical generation of clean fuel for automotive engines. This opinion article examines recent improvements in H(2) production by wild and mutant strains of Chlamydomonas reinhardtii - the green microalga currently considered the best eukaryotic H(2) producer. Here, we review various aspects of genetic and metabolic engineering of C. reinhardtii, as well as of process engineering. Additionally, we lay out possible scenarios that would lead to more efficient research approaches in the near future, as part of a consistent strategy for sustainable biohydrogen supply.
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