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Updated: May 30, 2026

Study of Protein-protein Interactions in Autophagy Research
Published on: September 9, 2017
The role of Tecpr1 in selective autophagy as a cargo receptor
Michinaga Ogawa1, Chihiro Sasakawa
1Division of Bacterial Infection, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Abstract:
Bacterial intrusion of host cells can be recognized by the innate immune system, including autophagy, via multiple cellular pathways. We have identified Tecpr1 as an Atg5-binding partner, and found that Tecpr1 interacts with the Atg12-Atg5-Atg16L1 complex via binding to Atg5. In Shigella infected cells, Tecpr1 colocalizes with Atg5 and LC3 at Shigella-containing phagophores. Tecpr1 activity is required for efficient autophagy to target bacteria, but a deficiency of Tecpr1 in host cells does not have a marked effect on canonical autophagy. Tecpr1 plays an important role in promoting selective autophagy via the WIPI-2-Tecpr1-Atg5 pathway in targeting bacteria, protein aggregates and damaged mitochondria.
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