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Updated: May 30, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Androgen action during prostate carcinogenesis

Diping Wang1, Donald J Tindall

  • 1Department of Urology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. wang.diping@mayo.edu

Methods in Molecular Biology (Clifton, N.J.)
|July 29, 2011
PubMed

Insights

Androgens and the androgen receptor (AR) are crucial for prostate cancer. This review explores how androgen-AR signaling impacts prostate cancer cell proliferation, apoptosis, and metastasis.

Area of Science:

  • Oncology
  • Endocrinology
  • Molecular Biology

Background:

  • Androgens are vital for prostate gland development and function.
  • Androgen-AR signaling is implicated in prostate cancer initiation and progression.

Purpose of the Study:

  • To review the role of androgen action in prostate carcinogenesis.
  • To discuss androgen-AR signaling in cell proliferation, apoptosis, and metastasis.

Main Methods:

  • Literature review of studies on androgen action in prostate cancer.

Main Results:

  • Androgen-AR signaling influences key prostate cancer events.
  • Specific impacts on cell proliferation, apoptosis, and metastasis are examined.

Conclusions:

  • Androgen-AR signaling is a central mechanism in prostate cancer.
  • Understanding these pathways is critical for therapeutic strategies.

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