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Vitamin C modulates the interaction between adipocytes and macrophages
Diego F Garcia-Diaz1, Javier Campion, Pablo Quintero
1Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain.
Molecular Nutrition & Food Research
|July 29, 2011
Summary
Vitamin C (VC) and insulin modulate inflammatory responses between adipocytes and macrophages. VC significantly impacts the pro-inflammatory state in this crucial cell interaction.
Area of Science:
- Biochemistry
- Cell Biology
- Immunology
Background:
- Adiposity promotes monocyte infiltration into adipose tissue, exacerbating inflammation.
- Antioxidant therapies are explored to mitigate inflammation associated with obesity.
Purpose of the Study:
- To investigate the effects of insulin and vitamin C (VC) on inflammatory markers in cocultures of adipocytes and macrophages.
Main Methods:
- Cocultures of 3T3-L1 adipocytes and RAW264.7 macrophages were treated with insulin and/or VC.
- Measurements included nitric oxide (NO) secretion, and expression/secretion of MCP-1, leptin, and apelin.
Main Results:
- Insulin and VC inhibited NO secretion in cocultures.
- MCP-1 expression and secretion were modulated by insulin and VC.
- Insulin induced apelin secretion, while VC inhibited it under insulin treatment.
Conclusions:
- Vitamin C significantly modulates the inflammatory environment resulting from adipocyte-macrophage interactions.
- These findings highlight the role of antioxidants in managing obesity-related inflammation.
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