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[The relationship between the serum ET and resistin concentration and the peripheral neuropathy in type 2 diabetes]
Li-mei Wang1, Chong-xian Wang, Dong-ming Zhang
1Department of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. lylimeiwang@live.cn
Aim:
To study patients with type 2 diabetes, endothelin (ET), resistin level and peripheral neuropathy (DPN) relationship.
Methods:
Second affiliated hospital of Zhengzhou university, department of endocrinology hospital of 60 patients with type 2 diabetes, the nerve electrophysiological examination of 20 cases were divided into DM group and 40 patients with DPN, and select the healthy control group of 30 cases. Radioimmunoassay and enzyme-linked immunosorbent assay of serum ET, resistin levels.
Results:
The DM group and the DPN serum ET, resistin levels were significantly higher (P<0.05), while the DPN group ET, resistin levels were significantly higher than that of DM group (P<0.05). Linear correlation analysis showed that patients with type 2 diabetes serum resistin levels were positively correlated with ET (r=0.436, P<0.01). Logistic regression analysis showed that duration, HbA1c, serum resistin level in ET and be associated with DPN are independent risk factors.
Conclusion:
Patients with type 2 diabetes ET, resistin levels are closely related with the DPN; patients with ET, is the abnormal increase of resistin levels may lead to the risk factors of DPN.
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