Related Experiment Video
Updated: May 30, 2026

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
Antiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitro
Suki M Y Lee1, W W Gai, Timothy K W Cheung
1Department of Microbiology, The University of Hong Kong, Hong Kong, China. suki@hkucc.hku.hk
Abstract:
A selective cyclooxygenase-2 (COX-2) inhibitor has been previously shown to suppress the hyper-induced pro-inflammatory responses in H5N1 infected primary human cells. Here, we demonstrate that COX-2 inhibitors suppress H5N1 virus replication in human macrophages suggesting that H5N1 virus replication (more so than seasonal H1N1 virus) is dependent on activation of COX-2 dependent signaling pathways in host cells. COX-2 and its downstream signaling pathways deserve detailed investigation as a novel therapeutic target for treatment of H5N1 disease.
More Related Videos
Related Concept Videos
Inhibitors of Viral Protein Synthesis
Inhibitors Of Virion Release
Antiviral Nucleoside Inhibitors
Inhibitors of Virion Maturation and Assembly
Subviral Agents
Antimicrobial Effectiveness

