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Updated: May 30, 2026

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
Published on: October 15, 2010
Effects of intracellular acidosis on endothelial function: an overview
Ettore Crimi1, Fabio Silvio Taccone, Teresa Infante
1Department of Anesthesia and Critical Care Medicine, Shands Hospital, University of Florida, Gainesville, FL 32608, USA.
Abstract:
The endothelium represents the largest functional organ in the human body playing an active role in vasoregulation, coagulation, inflammation, and microvascular permeability. Endothelium contributes to maintain vascular integrity, intravascular volume, and tissue oxygenation promoting inflammatory network response for local defense and repair. Acid-basis homeostasis is an important physiologic parameter that controls cell function, and changes in pH can influence vascular tone by regulating endothelium and vascular smooth muscle cells. This review presents a current perspective of the effects of intracellular acidosis on the function and the basic regulatory mechanisms of endothelial cells.
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