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Biometry of the corpus callosum in children: MR imaging reference data
1Service de Radiologie, AP-HP, Hôpital d'Enfants Armand-Trousseau, Paris, France. catherine.garel@trs.aphp.fr
Insights
This study provides easy-to-use reference biometry for the corpus callosum (CC) in children using MR imaging. The data offers normal values and growth patterns for key CC measurements, aiding clinical practice.
Area of Science:
- Pediatric Radiology
- Neuroimaging
- Developmental Neuroscience
Background:
- Limited availability of practical corpus callosum (CC) biometry data for pediatric MR imaging.
- Need for standardized reference values in routine clinical practice.
Purpose of the Study:
- To establish reference biometry of the CC in children using MR imaging.
- To provide data for daily clinical application in pediatric neuroimaging.
Main Methods:
- Retrospective analysis of cerebral MR imaging in 622 children (1 day to 15 years).
- Exclusion of preterm infants and those with cerebral malformations.
- Measurement of CC parameters: FOD, APD, LCC, GT, BT, IT, ST, S/T; evaluated inter/intraobserver agreement and sex effect.
Main Results:
- Provided normal values (3rd-97th percentile) for CC biometry.
- Identified distinct growth phases: rapid growth to 3 years, followed by slower or absent growth.
- CC modeling (IT/ST) complete by 3 years; FOD larger in boys from age 1; excellent inter/intraobserver agreement for most parameters.
Conclusions:
- The study offers easy and reproducible MR imaging biometry of the CC in children.
- The generated data supports clinical assessment and monitoring of pediatric brain development.
Background And Purpose:
The availability of data relating to the biometry of the CC in children that are easy to use in daily practice is limited. We present a reference biometry of the CC in MR imaging in a large cohort of children.
Materials And Methods:
Cerebral MR imaging studies of children with normal examination findings were selected retrospectively. Children born preterm and those with or at risk of developing cerebral malformations were excluded. The following parameters were measured: FOD, APD, LCC, GT, BT, IT, ST, and the S/T. Inter- and intraobserver agreement and sex effect were evaluated.
Results:
Six hundred twenty-two children were included (320 boys, 302 girls), ranging from 1 day to 15 years of age. Normal values (from the 3rd to 97th percentile) are provided for each parameter. All parameters showed rapid growth up to 3 years of age followed by slower (FOD, APD, LCC, GT and ST) or absent (S/T) growth. Growth of BT and IT was completed by 7-8 years. CC modeling (IT/ST) was completed by 3 years. FOD was larger in boys from the age of 1 year (statistically significant). The other parameters did not show any sex effect. Inter- and intraobserver agreement was excellent for all parameters except for IT.
Conclusions:
As measured, our data result in easy and reproducible MR imaging biometry of the CC in children.
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