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Related Concept Videos

Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Pancreatic Juice and Secretion01:26

Pancreatic Juice and Secretion

Pancreatic juice is a clear fluid produced by the pancreas, containing water, salts, sodium bicarbonate, and enzymes vital for digestion in the small intestine. It helps break down large molecules, facilitating nutrient absorption.
When acidic chyme from the stomach enters the duodenum, it triggers the release of secretin, a hormone that prompts pancreatic juice secretion. After a fatty meal, cholecystokinin, another hormone, stimulates gallbladder contraction and enhances enzyme-rich...
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Cells and Secretions of the Pancreas01:16

Cells and Secretions of the Pancreas

The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...

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Related Experiment Video

Updated: May 30, 2026

Pancreatic Islet Isolation and Purification from Lewis Rats Using Enzymatic Digestion and Density-Gradient Separation
07:44

Pancreatic Islet Isolation and Purification from Lewis Rats Using Enzymatic Digestion and Density-Gradient Separation

Published on: April 3, 2026

Pancreatic enzyme supplementation.

Heather A Wier1, Robert J Kuhn

  • 1Centennial Medical Center, Nashville, Tennessee, USA.

Current Opinion in Pediatrics
|July 30, 2011
PubMed
Summary
This summary is machine-generated.

New pancreatic enzyme replacement therapies (PERT) show improved fat and nitrogen absorption in cystic fibrosis patients. Clinicians should continue to individualize dosing for optimal patient response.

More Related Videos

Assessing the Secretory Capacity of Pancreatic Acinar Cells
09:52

Assessing the Secretory Capacity of Pancreatic Acinar Cells

Published on: August 28, 2014

Related Experiment Videos

Last Updated: May 30, 2026

Pancreatic Islet Isolation and Purification from Lewis Rats Using Enzymatic Digestion and Density-Gradient Separation
07:44

Pancreatic Islet Isolation and Purification from Lewis Rats Using Enzymatic Digestion and Density-Gradient Separation

Published on: April 3, 2026

Assessing the Secretory Capacity of Pancreatic Acinar Cells
09:52

Assessing the Secretory Capacity of Pancreatic Acinar Cells

Published on: August 28, 2014

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Biochemistry

Background:

  • Pancreatic enzyme replacement therapy (PERT) is crucial for managing pancreatic insufficiency.
  • FDA regulations in 2010 mandated marketing approval for PERT, leading to new formulations.
  • Patients previously on long-standing PERT required transitions to new products.

Purpose of the Study:

  • To review clinical data on newly approved PERT products.
  • To summarize the efficacy and safety of current PERT formulations.
  • To discuss the general use of these updated pancreatic enzyme therapies.

Main Methods:

  • Review of clinical trial data for new PERT products.
  • Comparison of fat and nitrogen absorption with previous preparations.
  • Assessment of side-effect profiles against placebo.

Main Results:

  • New PERT formulations (Creon, Zenpep, Pancreaze) demonstrated comparable or improved fat and nitrogen absorption.
  • All tested PERT preparations showed superiority over placebo.
  • Adverse events were similar to placebo, with ongoing evaluation of new options like non-porcine PERT.

Conclusions:

  • Newly approved PERT products effectively improve nutrient absorption in pancreatic insufficiency.
  • Individual patient variability necessitates continued dose titration for optimal outcomes.
  • Ongoing research aims to provide further PERT options, including non-porcine alternatives.