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Epidemiological and clinical features of hepatitis B virus related liver failure in China

Chen Liu1, Yu-Ming Wang, Ke Fan

  • 1Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.

World Journal of Gastroenterology
|July 30, 2011
PubMed

Insights

This study analyzed hepatitis B virus (HBV) liver failure in China, finding alcohol and complications impact prognosis. Prothrombin activity (PTA) and complications are key indicators for estimating outcomes.

Area of Science:

  • Hepatology
  • Epidemiology
  • Viral Hepatitis Research

Background:

  • Hepatitis B virus (HBV) infection remains a significant global health concern.
  • HBV-related liver failure presents a critical clinical challenge, particularly in endemic regions like China.
  • Understanding the demographic and clinical profiles of patients with HBV-related liver failure is crucial for effective management.

Purpose of the Study:

  • To investigate the epidemiological and clinical characteristics of HBV-related liver failure in a Chinese patient cohort.
  • To identify factors influencing the prognosis of patients suffering from HBV-related liver failure.

Main Methods:

  • A retrospective study design was employed.
  • Data from 1066 patients diagnosed with HBV-related liver failure in Southwest China were analyzed.
  • Logistic regression analysis was used to determine prognostic factors.

Main Results:

  • The study identified a predominantly male patient population, with young and middle-aged individuals, farmers, and laborers constituting the majority.
  • A significant proportion of patients had a family history of HBV-related liver failure and a history of alcohol consumption.
  • Key clinical manifestations included hypodynamia, anorexia, and abdominal distension, with altered liver enzymes (ALT, TBIL) observed in many patients.
  • Univariate and multifactor logistic regression revealed that alcohol consumption, ascites, hepatorenal syndrome, infection, number of complications, and prothrombin activity (PTA) were significantly associated with patient prognosis.

Conclusions:

  • Alcohol consumption negatively influences the condition and prognosis of patients with HBV-related liver failure.
  • Prothrombin activity (PTA) and the presence of complications are independent predictors for estimating the prognosis of HBV-related liver failure.
  • These findings underscore the importance of considering lifestyle factors and complication burden in managing HBV-related liver failure.
Abstract

Keywords:
Chronic hepatitis BEpidemiologyHepatitis B virus related liver failurePrognosis

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