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Updated: May 30, 2026

The Frequency Domain Thermoreflectance Technique for Thermal Property Measurements
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Ultrafast 1D MR thermometry using phase or frequency mapping.

Chang-Sheng Mei1, Robert V Mulkern, Koichi Oshio

  • 1Department of Physics, Boston College, Chestnut Hill, MA, USA. meic@bwh.harvard.edu

Magma (New York, N.Y.)
|July 30, 2011
PubMed
Summary
This summary is machine-generated.

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Corrigendum: Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy (2016<i>Phys. Med. Biol</i>.<b>61</b>R206).

Physics in medicine and biology·2026

This study presents an ultrafast MRI method for real-time temperature monitoring during ultrasound exposures in moving organs. The technique achieves high temporal resolution, enabling precise tracking of thermal effects in dynamic biological tissues.

Area of Science:

  • Medical Imaging
  • Biophysics
  • Ultrasound Technology

Background:

  • Accurate temperature monitoring is crucial for therapeutic ultrasound applications.
  • Existing methods may lack the speed required for dynamic tissues.
  • Moving organs present unique challenges for real-time monitoring.

Purpose of the Study:

  • To develop and validate an ultrafast MRI-based temperature monitoring technique.
  • To enable real-time temperature assessment during rapid ultrasound exposures.
  • To apply the method in moving organs, including the human heart.

Main Methods:

  • Utilized slice-selective RF pulses and gradient echo trains for echo solicitation.
  • Compared phase changes to standard gradient-echo thermometry in a gel phantom.

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Last Updated: May 30, 2026

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  • Evaluated signal-to-noise ratio (SNR) in vivo and tested feasibility in a human heart.

    • Main Results:

    • Achieved a high temperature sampling rate of 19 Hz at 3T in a gel phantom.
    • Demonstrated good correlation (R = 0.98 ± 0.03) between echoes and temperature measurements.
    • Successfully acquired water frequency in beating heart muscle at 5 Hz during breath-hold.

    Conclusions:

    • Ultrafast thermometry using phase or frequency monitoring along single columns is feasible.
    • Temporal resolution around 50 ms allows monitoring of focal heating from short ultrasound pulses.
    • This method holds promise for safe and effective therapeutic ultrasound applications.