Related Experiment Video
Updated: May 30, 2026
Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
Published on: April 7, 2023
[Prevention of bone loss in a patient receiving androgen deprivation therapy]
1Abteilung für Urologie, Kinderurologie und Uro-Onkologie, St. Josef-Hospital Troisdorf, Hospitalstraße 45, Troisdorf, Germany. norbert.rolfes@josef-hospital.de
Abstract:
Bone loss is a frequent side effect of androgen deprivation therapy, which leads to a significant number of pathologic fractures. Prevention of osteoporosis aims at reducing skeletal-related events. The RANK ligand antibody denosumab and bisphosphonates are used for this indication. Denosumab has been shown to increase bone density and to reduce the incidence of fractures at any location by 72%. Bone density can also be increased by bisphosphonates; however, there is no conclusive evidence so far that the fracture rate can be reduced significantly. Therefore guidelines do not recommend use of these substances for this indication.
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