Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Cerebrospinal Fluid01:21

Cerebrospinal Fluid

Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain.
The Blood-brain Barrier00:49

The Blood-brain Barrier

Overview
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same author

Navigating a crowded developing brain leaves neurons with broken DNA.

Nature·2026
Same author

Somatic cancer variants enriched in Alzheimer's disease microglia-like cells drive inflammatory and proliferative states.

Cell·2026
Same author

Genomic approaches for understanding the evolution of the human brain.

Nature neuroscience·2026
Same author

Somatic mosaicism in ALS and FTD identifies focal mutations associated with widespread degeneration.

Nature genetics·2026
Same author

Choroid plexus inflammation in bipolar disorder.

Brain, behavior, and immunity·2026

Related Experiment Video

Updated: May 30, 2026

Isolation of Cerebrospinal Fluid from Rodent Embryos for use with Dissected Cerebral Cortical Explants
09:47

Isolation of Cerebrospinal Fluid from Rodent Embryos for use with Dissected Cerebral Cortical Explants

Published on: March 11, 2013

Neurogenesis at the brain-cerebrospinal fluid interface.

Maria K Lehtinen1, Christopher A Walsh

  • 1Division of Genetics, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA. maria.lehtinen@childrens.harvard.edu

Annual Review of Cell and Developmental Biology
|August 2, 2011
PubMed
Summary

Cerebral progenitor cells use intrinsic polarity and external cerebrospinal fluid signals to control neurogenesis. Understanding these cues is vital for brain development and repair.

More Related Videos

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis
06:24

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis

Published on: October 7, 2021

Manual Drainage of the Zebrafish Embryonic Brain Ventricles
06:17

Manual Drainage of the Zebrafish Embryonic Brain Ventricles

Published on: December 16, 2012

Related Experiment Videos

Last Updated: May 30, 2026

Isolation of Cerebrospinal Fluid from Rodent Embryos for use with Dissected Cerebral Cortical Explants
09:47

Isolation of Cerebrospinal Fluid from Rodent Embryos for use with Dissected Cerebral Cortical Explants

Published on: March 11, 2013

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis
06:24

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis

Published on: October 7, 2021

Manual Drainage of the Zebrafish Embryonic Brain Ventricles
06:17

Manual Drainage of the Zebrafish Embryonic Brain Ventricles

Published on: December 16, 2012

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Cerebral cortical progenitor cells (CPCs) are crucial for neurogenesis, integrating intrinsic and extrinsic signals.
  • Apical-basal polarity, mediated by cell junctions and proteins, is a key intrinsic mechanism.
  • The role of extrinsic cues, particularly cerebrospinal fluid (CSF), in instructing CPCs remains less understood.

Purpose of the Study:

  • To review how apical-basal polarity in CPCs regulates cell fate.
  • To explore how CPCs interact with diffusible signals from the cerebrospinal fluid.
  • To summarize signaling factors within the CSF that guide neurogenesis.

Main Methods:

  • Literature review of studies on neural progenitor cell regulation.
  • Analysis of molecular mechanisms underlying apical-basal polarity in CPCs.
  • Examination of research on cerebrospinal fluid signaling in neurogenesis.

Main Results:

  • Apical-basal polarity is essential for progenitor cell fate determination and mitotic spindle orientation.
  • Cerebrospinal fluid provides critical growth and survival cues to neural progenitor cells.
  • CPCs sample and respond to diffusible signals from the CSF via their apical complex.

Conclusions:

  • Apical-basal polarity enables CPCs to integrate intrinsic and extrinsic signals for neurogenesis.
  • Cerebrospinal fluid acts as a signaling medium, delivering crucial factors for brain development.
  • Further research into CSF-derived signaling factors can illuminate therapeutic strategies for neurological disorders.