Related Experiment Video

Updated: May 30, 2026

Rapid Quantification of Oxidized and Reduced Forms of Glutathione Using Ortho -phthalaldehyde in Cultured Mammalian Cells In Vitro
03:35

Rapid Quantification of Oxidized and Reduced Forms of Glutathione Using Ortho -phthalaldehyde in Cultured Mammalian Cells In Vitro

Published on: June 28, 2024

Unbalanced oxidant-antioxidant status and its effects in pediatric diseases

Valentina Chiavaroli1, Cosimo Giannini, Stefania De Marco

  • 1University of Chieti, Italy.

Redox Report : Communications in Free Radical Research
|August 2, 2011
PubMed

Insights

Oxidative stress, an imbalance in the body's antioxidant defenses, impacts childhood diseases. Early diagnosis and intervention are crucial for managing oxidative damage in children.

Area of Science:

  • Pediatrics
  • Biochemistry
  • Pathophysiology

Background:

  • Oxidative stress arises from an imbalance between reactive oxygen species production and antioxidant capacity.
  • This imbalance contributes to disease pathogenesis in adults and plays a role in childhood pathologies.
  • Unbalanced oxidant-antioxidant status can cause toxic effects even in infancy.

Purpose of the Study:

  • To review the current understanding of the relationship between oxidative stress and systemic diseases in children.
  • To focus on pre-pubertal children to minimize confounding factors like puberty-induced metabolic changes.
  • To highlight the importance of early identification and diagnosis for therapeutic interventions.

Main Methods:

  • Comprehensive literature review.
  • Focus on studies involving pre-pubertal children.
  • Analysis of the role of oxidative stress in childhood systemic diseases.

Main Results:

  • Oxidative stress significantly influences the progression of various pathologies during childhood.
  • The pre-pubertal age group provides a unique model to study oxidative stress without puberty-related metabolic interference.
  • Evidence suggests that early detection of oxidative imbalance is key.

Conclusions:

  • Oxidative stress is a critical factor in childhood disease development.
  • Early diagnosis of oxidative stress in children is essential for timely therapeutic strategies.
  • Targeting oxidative stress can mitigate damage and improve outcomes in pediatric patients.

More Related Videos

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors09:33

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

Analysis of Oxidative Stress in Zebrafish Embryos11:05

Analysis of Oxidative Stress in Zebrafish Embryos

Published on: July 7, 2014

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Balancing Redox Equations02:58

Balancing Redox Equations

Electrochemistry is the science involved in the interconversion of electrical and chemical reactions. Such reactions are called reduction-oxidation, or redox reactions. These important reactions are defined by changes in oxidation states for one or more reactant elements and include a subset of reactions involving the transfer of electrons between reactant species. Electrochemistry as a field has evolved to yield sufficient insights on the fundamental principles of redox chemistry and multiple...
Bioactivation and Tissue Toxicity01:25

Bioactivation and Tissue Toxicity

Bioactivation is a metabolic process that transforms less reactive substances into highly reactive metabolites, initiating tissue toxicity. This transformation can lead to various toxic effects, including carcinogenesis and teratogenesis. Reactive metabolites are classified into two main types: electrophiles and free radicals.Electrophiles are electron-deficient species and are produced primarily by the enzyme cytochrome P-450 during the metabolism of compounds containing carbon, nitrogen, or...
Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Peroxisomes01:24

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...