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10:28
A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
Neurologic disorders and hepatitis E, France, 2010
Laura-Anne Despierres1, Elsa Kaphan, Shahram Attarian
1Centre Hospitalo-Universitaire Timone, Marseille, France.
Emerging Infectious Diseases
|August 2, 2011
Summary
Hepatitis E can cause neurological issues like meningitis and polyradiculoneuropathy. Testing for the hepatitis E virus is recommended for patients with neurological symptoms and liver damage.
Area of Science:
- Neurology
- Infectious Diseases
- Hepatology
Background:
- Hepatitis E virus (HEV) infection is a significant cause of acute hepatitis globally.
- Neurological manifestations of HEV are rare but increasingly recognized.
Observation:
- Two adult patients presented with meningitis and diffuse neuralgic pain or polyradiculoneuropathy.
- Both patients had polymerase chain reaction (PCR)-documented acute hepatitis E.
Findings:
- This case series links HEV infection to severe neurological conditions, specifically meningitis and polyradiculoneuropathy.
- The findings highlight a potential etiological connection between acute HEV and these neurological syndromes.
Implications:
- Diagnostic testing for hepatitis E virus should be considered in patients presenting with neurological symptoms alongside unexplained liver cytolysis.
- Early diagnosis of HEV in patients with neurological symptoms can lead to timely treatment and potentially better outcomes.
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