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Updated: May 30, 2026

Preparation of a Corannulene-functionalized Hexahelicene by Copper(I)-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
Published on: September 18, 2016
Fragrance material review on cyclohexadecanone.
D McGinty1, C S Letizia, A M Api
1Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. dmcginty@RIFM.org
Cyclohexadecanone, a macrocyclic ketone, was reviewed for toxicologic and dermatologic safety in fragrances. Available data indicate it is safe for use, with comprehensive safety assessments published separately.
Area of Science:
- Toxicology
- Dermatology
- Fragrance Chemistry
Background:
- Cyclohexadecanone is a macrocyclic ketone used in fragrances.
- It belongs to a group of 11 structurally diverse C15-C17 ketones.
Purpose of the Study:
- To present a toxicologic and dermatologic review of cyclohexadecanone.
- To summarize available safety data for this fragrance ingredient.
Main Methods:
- Evaluation and summarization of existing toxicology and dermatology studies.
- Data included physical properties, acute toxicity, irritation, sensitization, repeated dose, and genotoxicity.
Main Results:
- A comprehensive summary of available safety data for cyclohexadecanone was compiled.
- The review covers physical properties, acute toxicity, skin and eye irritation, sensitization, repeated dose toxicity, and genotoxicity.
Conclusions:
- Cyclohexadecanone data were evaluated and summarized.
- A full safety assessment of macrocyclic ketones and derivatives, including cyclohexadecanone, is available in a companion publication (Belsito et al., 2011).
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