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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

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Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
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Potato Virus X-Based microRNA Silencing (VbMS) In Potato.
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Potato Virus X-Based microRNA Silencing (VbMS) In Potato.

Published on: May 11, 2020

MicroRNAs and vascular (dys)function.

Dorothee Hartmann1, Thomas Thum

  • 1Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany.

Vascular Pharmacology
|August 2, 2011
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) regulate cellular functions and are linked to cardiovascular diseases. This review highlights vascular-specific miRNAs, their roles in vascular dysfunction, and therapeutic potential.

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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
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Last Updated: May 30, 2026

Potato Virus X-Based microRNA Silencing (VbMS) In Potato.
11:51

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Published on: May 11, 2020

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiovascular Research

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression.
  • Aberrant miRNA expression is implicated in various human diseases, notably cardiovascular dysfunction.
  • Understanding miRNA roles is crucial for disease mechanisms.

Purpose of the Study:

  • To review current knowledge on vascular-specific miRNAs.
  • To elucidate their targets and mechanisms in the vasculature.
  • To explore miRNA-based therapeutic strategies for vascular dysfunction.

Main Methods:

  • Literature review of recent studies on vascular miRNAs.
  • Analysis of miRNA identification and target validation methods.
  • Synthesis of data on miRNA functions in vascular biology.

Main Results:

  • Identification of specific miRNAs regulating vascular functions.
  • Elucidation of molecular pathways targeted by these miRNAs.
  • Evidence supporting miRNA involvement in vascular disease pathogenesis.

Conclusions:

  • Vascular-specific miRNAs play critical roles in cardiovascular health and disease.
  • Targeting these miRNAs offers a promising therapeutic avenue.
  • Further research is needed to translate these findings into clinical practice.