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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
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Published on: August 12, 2017

Myeloid derived suppressor cells in transplantation

Jason R Lees1, Agnes M Azimzadeh, Jonathan S Bromberg

  • 1Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.

Current Opinion in Immunology
|August 2, 2011
PubMed

Myeloid derived suppressor cells (MDSC) are a heterogeneous population of hematopoietic derived cell precursors that can suppress immune responses in a variety of inflammatory settings. Here we review recent studies detailing expansion of phenotypically and functionally disparate MDSC. Findings related to MDSC accumulation, activation, and mechanisms utilized in immune suppression are presented. Further, we discuss recent reports that suggest MDSC are expanded during transplantation and that modulation of MDSC can participate in preventing graft rejection.

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