Microbial conversion of curcumin into colorless hydroderivatives by the endophytic fungus Diaporthe sp. associated with Curcuma longa
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Shoji Maehara1, Michiteru Ikeda, Hiroyuki Haraguchi
1Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan.
Chemical & Pharmaceutical Bulletin
|August 2, 2011
Abstract:
We investigated the microbial conversion of curcumin (1) using endophytic fungi associated with the rhizome of Curcuma longa (Zingiberaceae). We found that Diaporthe sp., an endophytic filamentous fungus, converts curcumin (1) into four colorless derivatives, namely (3R,5R)-tetrahydrocurcumin (2), a novel (3R,5S)-hexahydrocurcumin (3) named neohexahydrocurcumin, (3S,5S)-octahydrocurcumin (4) and meso-octahydrocurcumin (5).
