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Updated: May 30, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics
Published on: April 10, 2026
The antibacterial peptide ABP-CM4: the current state of its production and applications
Jian Feng Li1, Jie Zhang, Xing Zhou Xu
1Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, Life Science College, Nanjing Normal University, 210046, Nanjing, Jiangsu, People's Republic of China.
Abstract:
The increasing resistance of bacteria and fungi to currently available antibiotics is a major concern worldwide, leading to enormous efforts to develop new antibiotics with new modes of actions. Antibacterial peptide CM4 (ABP-CM4) is a small cationic peptide with broad-spectrum activities against bacteria, fungi, and tumor cells, which may possibly be used as a promising candidate for a new antibiotic. For pharmaceutical applications, a large quantity of antimicrobial peptides needs to be produced economically. In this communication, the progress in the structural characteristics, heterologous production, and biological evaluation of ABP-CM4 are reviewed.
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