Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 16, 2026

Tracking Electrochemistry on Single Nanoparticles with Surface-Enhanced Raman Scattering Spectroscopy and Microscopy
10:59

Tracking Electrochemistry on Single Nanoparticles with Surface-Enhanced Raman Scattering Spectroscopy and Microscopy

Published on: May 12, 2023

Surface analysis using shell-isolated nanoparticle-enhanced Raman spectroscopy.

Jian Feng Li1, Xiang Dong Tian, Song Bo Li

  • 1State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.

Nature Protocols
|December 15, 2012
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Situ Raman Spectroscopy Reveals the Dynamic Evolution and Ethanol Dependence of SEI Structure in Li-Mediated N<sub>2</sub> Reduction Reaction.

Journal of the American Chemical Society·2026
Same author

Sequencing Ablation and Systemic Therapy in Colorectal Liver Oligometastases: An Upfront versus Delayed Approach Nationwide Analysis.

Radiology·2026
Same author

HA thermostability mutations S84F, G167N, and D168N potentiate H9N2 virus transmission in a warming environment.

Emerging microbes & infections·2026
Same author

RNF213 isoform 2 restricts Zika virus through antiviral signaling and viral protein degradation.

iScience·2026
Same author

AirNet: A Deep Learning-Driven Auto Baseline Correction Algorithm Balancing Global Smoothness and Local Fidelity.

Analytical chemistry·2026
Same author

Efficient large-fragment isogenic sequence replacement in rice via prime editing with engineered reverse transcriptase variants.

Journal of advanced research·2026
Same journal

iMUT-seq mapping of DSB-induced mutations with high sensitivity at single-nucleotide resolution.

Nature protocols·2026
Same journal

An assay to quantify sexual commitment and stage conversion in the human malaria parasite Plasmodium falciparum.

Nature protocols·2026
Same journal

Author Correction: Direct inoculation of bioreactor-controlled stirred suspension culture with cryopreserved human pluripotent stem cells.

Nature protocols·2026
Same journal

High-throughput measurements of protein domain functions using magnetic separation.

Nature protocols·2026
Same journal

Inducing physiological polarity and performing gene editing using CRISPR-Cas9 in human trophoblast organoids.

Nature protocols·2026
Same journal

Photocatalytic low-temperature defluorination of PTFE.

Nature protocols·2026
See all related articles

Shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) expands surface-enhanced Raman scattering (SERS) applications to diverse surfaces. This novel technique utilizes gold-core silica-shell nanoparticles for universal SERS analysis.

Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Spectroscopy

Background:

  • Surface-enhanced Raman scattering (SERS) offers high sensitivity but is limited to specific metal substrates.
  • Existing SERS techniques struggle with diverse material compositions and surface morphologies.

Purpose of the Study:

  • To develop a universally applicable SERS technique.
  • To enable SERS analysis on a wide range of surfaces, overcoming previous limitations.

Main Methods:

  • Invented shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) using gold-core silica-shell nanoparticles (Au@SiO(2) NPs).
  • Developed a protocol for preparing SHINs with controlled core sizes, shapes, and shell thicknesses.
  • Applied SHINERS to various surfaces including single-crystal metals, silicon wafers, ZnO nanorods, bacteria, and fruit.

More Related Videos

Ultrafast Laser-Ablated Nanoparticles and Nanostructures for Surface-Enhanced Raman Scattering-Based Sensing Applications
06:15

Ultrafast Laser-Ablated Nanoparticles and Nanostructures for Surface-Enhanced Raman Scattering-Based Sensing Applications

Published on: June 16, 2023

Label-Free Surface-Enhanced Raman Scattering Bioanalysis Based on Au@Carbon Dot Nanoprobes
06:19

Label-Free Surface-Enhanced Raman Scattering Bioanalysis Based on Au@Carbon Dot Nanoprobes

Published on: June 9, 2023

Related Experiment Videos

Last Updated: May 16, 2026

Tracking Electrochemistry on Single Nanoparticles with Surface-Enhanced Raman Scattering Spectroscopy and Microscopy
10:59

Tracking Electrochemistry on Single Nanoparticles with Surface-Enhanced Raman Scattering Spectroscopy and Microscopy

Published on: May 12, 2023

Ultrafast Laser-Ablated Nanoparticles and Nanostructures for Surface-Enhanced Raman Scattering-Based Sensing Applications
06:15

Ultrafast Laser-Ablated Nanoparticles and Nanostructures for Surface-Enhanced Raman Scattering-Based Sensing Applications

Published on: June 16, 2023

Label-Free Surface-Enhanced Raman Scattering Bioanalysis Based on Au@Carbon Dot Nanoprobes
06:19

Label-Free Surface-Enhanced Raman Scattering Bioanalysis Based on Au@Carbon Dot Nanoprobes

Published on: June 9, 2023

Main Results:

  • SHINERS demonstrated universal applicability across different surface compositions and morphologies.
  • SHINs preparation is efficient, taking approximately 3 hours.
  • Subsequent SHINERS measurements require only 1-2 hours per procedure.

Conclusions:

  • SHINERS significantly broadens the scope of SERS applications.
  • The technique provides a versatile and efficient method for vibrational spectroscopy on diverse samples.
  • This advancement opens new avenues for surface analysis in various scientific fields.