Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Toxicity Testing in Animals

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

Ethics in Research

Ethics in Research

Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Laboratory Guidelines for Animal Care.

Methods in molecular biology (Clifton, N.J.)·2019

Same author

Distribution of phenolic compounds and antioxidant capacity in apples tissues during ripening.

Journal of food science and technology·2017

Same author

INDs for PET molecular imaging probes-approach by an academic institution.

Molecular imaging and biology·2014

Same author

Response to Protocol Review Scenario: the economy of research.

Lab animal·2014

Same author

Classification of juices and fermented beverages made from unripe, ripe and senescent apples based on the aromatic profile using chemometrics.

Food chemistry·2013

Search research articles

Related Experiment Video

Updated: May 30, 2026

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative

Published on: August 21, 2021

Laboratory guidelines for animal care.

Marcelo Couto¹

¹UCLA School of Medicine-DLAM, Los Angeles, CA, USA. mcouto@mednet.ucla.edu

Methods in Molecular Biology (Clifton, N.J.)

|August 2, 2011

Summary

This summary is machine-generated.

Animal research requires ethical conduct and strict adherence to regulations to ensure animal welfare and research integrity. Understanding and complying with guidelines, alongside building strong institutional relationships, is crucial for researchers to prevent negative consequences.

More Related Videos

Training Laboratory Rabbits to Refine Routine Husbandry Procedures

Training Laboratory Rabbits to Refine Routine Husbandry Procedures

Published on: February 16, 2024

Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 2. General Practices

Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 2. General Practices

Published on: October 3, 2016

Related Experiment Videos

Last Updated: May 30, 2026

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative

Transition of Farm Pigs to Research Pigs using a Designated Checklist followed by Initiation of Clicker Training - a Refinement Initiative

Published on: August 21, 2021

Training Laboratory Rabbits to Refine Routine Husbandry Procedures

Training Laboratory Rabbits to Refine Routine Husbandry Procedures

Published on: February 16, 2024

Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 2. General Practices

Safety Precautions and Operating Procedures in an (A)BSL-4 Laboratory: 2. General Practices

Published on: October 3, 2016

Area of Science:

* Ethical considerations in biomedical and scientific research involving animal models.
* Regulatory compliance in laboratory animal science and experimentation.

Background:

* Animal research is ethically complex due to the use of sentient subjects in procedures that may cause distress or pain.
* The necessity of conducting animal studies compassionately, prioritizing animal quality of life during experimentation.

Framework:

* Comprehensive regulation of animal research at federal, state, and institutional levels.
* Importance of researchers understanding and adhering to established protocols and legal requirements.

Implementation:

* Minimizing occupational hazards for researchers and staff through knowledge of procedures.
* Preventing criticism from animal rights organizations by avoiding noncompliance with protocols and regulations.
* Strategies for researchers to build trust and rapport with veterinary staff, Institutional Animal Care and Use Committees (IACUCs), and administrators.

Implications:

* Avoiding serious repercussions of regulatory noncompliance, including protocol suspension and loss of funding.
* Ensuring the integrity and continuity of scientific investigations through diligent oversight.
* Promoting a culture of responsibility and ethical practice in the animal research community.